GAMBARAN HISTOPATOLOGI HATI TERHADAP PAPARAN LOGAM BERAT TIMBAL (Pb) PADA TIKUS PUTIH (Rattus norvegicus)

Nisa Anugrah, Nisa (2025) GAMBARAN HISTOPATOLOGI HATI TERHADAP PAPARAN LOGAM BERAT TIMBAL (Pb) PADA TIKUS PUTIH (Rattus norvegicus). Skripsi thesis, Universitas Perintis Indonesia.

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Abstract

Lead (Pb) is a toxic environmental pollutant that can negatively affect health, particularly the liver. This study aimed to determine blood lead (Pb) levels and the histopathological features of the liver in white rats (Rattus norvegicus) after Pb exposure. This was a laboratory experimental study using a post-test only control group design. A total of 7 white rats were used, divided into 2 groups: 3 rats as the negative control and 4 rats as the treatment group injected intraperitoneally with Pb(NO₃)₂ at a dose of 1000 mg/L. Blood lead levels were measured using Atomic Absorption Spectrophotometry (AAS), while liver histopathology was examined with Hematoxylin-Eosin (HE) staining.The results showed that the mean blood lead level in the control group was 0.0195 mg/L, which significantly increased in the 3 hour treatment group (1.1516 mg/L) and the 6-hour treatment group (1.2696 mg/L). Histopathological examination revealed normal liver structures in the control group, parenchymatous degeneration in the 3-hour treatment group, and more severe damage, such as hydropic degeneration and necrosis, in the 6 hour treatment group.It can be concluded that the histopathological features of the liver in white rats (Rattus norvegicus) undergo gradual changes due to Pb exposure, starting from normal conditions to parenchymatous degeneration, hydropic degeneration, and necrosis, depending on the duration of exposure. Keywords: Lead (Pb), liver histopathology, Rattus norvegicus, Atomic Absorption Spectrophotometry (AAS).

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