MEMBANDINGKAN JUMLAH MONOSIT SEBELUM DAN SESUDAH PEMBERIAN EKSTRAK BUNGA CENGKEH (SYZYGIUM AROMATICUM) PADA TIKUS HIPERGLIKEMIA

Nurul Atvinai, Nurul and UNSPECIFIED (2025) MEMBANDINGKAN JUMLAH MONOSIT SEBELUM DAN SESUDAH PEMBERIAN EKSTRAK BUNGA CENGKEH (SYZYGIUM AROMATICUM) PADA TIKUS HIPERGLIKEMIA. Skripsi thesis, Universitas Perintis Indonesia.

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Abstract

Chronic hyperglycemia can trigger an inflammatory process characterized by an increase in the number of monocytes in the blood circulation. Clove flower extract (Syzygium aromaticum) is known to contain active anti-inflammatory compounds that have the potential to reduce the number of monocytes. This study aimed to compare the number of monocytes before and after the administration of clove flower extract in hyperglycemia model mice. The research design used was experimental using white rats (Rattus norvegicus). Monocyte counts were measured before and after the intervention, then analyzed using an independent t-test . The results showed that before the administration of the extract, there was no significant difference between the comparison and treatment groups (p = 0.711). However, after the administration of the extract, there was a significant decrease in the number of monocytes in the treatment group compared to the comparator (p = 0.00). Thus, clove flower extract was shown to be able to significantly reduce the number of monocytes in hyperglycemic mice, which shows potential as an anti inflammatory agent.

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