UJI AKTIVITAS ANTIINFLAMASI EKSTRAK KAPANG ENDOFIT UMBI DAHLIA (Dahlia variabilis) TERHADAP BIOMARKER INFLAMASI C - REACTIVE PROTEIN PADA TIKUS PUTIH (Rattus novergicus)

Sakina Natasya Putri, Sakina (2025) UJI AKTIVITAS ANTIINFLAMASI EKSTRAK KAPANG ENDOFIT UMBI DAHLIA (Dahlia variabilis) TERHADAP BIOMARKER INFLAMASI C - REACTIVE PROTEIN PADA TIKUS PUTIH (Rattus novergicus). Skripsi thesis, Universitas Perintis Indonesia.

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Abstract

chronic. Systemic inflammatory markers such as C-Reactive Protein (CRP) serve as important indicators in assessing this condition. This study aimed to determine the effectiveness of ethyl acetate extract of endophytic fungi from dahlia tubers (Dahlia variabilis) on CRP levels and liver weight in inflamed white rats (Rattus norvegicus). A post-test only control group design was used with five groups: negative control, positive control, and three treatment groups receiving extract doses of 5%, 10%, and 15%. The extract was applied topically in ointment form for 14 days. Results showed that the 10% and 15% extract doses significantly reduced both CRP levels and liver weight compared to the positive control (p < 0.05). In conclusion, the ethyl acetate extract of endophytic fungi from dahlia tubers has potential as an effective natural-based anti inflammatory agent. Keywords: Dahlia tuber, CRP, inflammation, ethyl acetate extract, white rats.

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